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Article

GABA-receptive microglia selectively sculpt developing inhibitory circuits.

Cell - 22 Jul 2021

Favuzzi Emilia, Huang Shuhan, Saldi Giuseppe A, Binan Loïc, Ibrahim Leena A, Fernández-Otero Marian, Cao Yuqing, Zeine Ayman, Sefah Adwoa, Zheng Karen, Xu Qing, Khlestova Elizaveta, Farhi Samouil L, Bonneau Richard, Datta Sandeep Robert, Stevens Beth, Fishell Gord

Abstract excerpt

Microglia, the resident immune cells of the brain, have emerged as crucial regulators of synaptic refinement and brain wiring. However, whether the remodeling of distinct synapse types during development is mediated by specialized microglia is unknown. Here, we show that GABA-receptive microglia selectively interact with inhibitory cortical synapses during a critical window of mouse postnatal development. GABA...

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Identifiers

PMID: 34233165
DOI: 10.1016/j.cell.2021.06.018
PMCID: PMC9122259

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