Osmosensing in trabecular meshwork cells

Abstract excerpt

<h4>ABSTRACT</h4> Aqueous humor drainage from the anterior eye constitutes a key determinant of intraocular pressure (IOP) under homeostatic and pathological conditions. Swelling of the trabecular meshwork (TM) increases its flow resistance but the mechanisms that sense and transduce osmotic gradients remain poorly understood. We used optical molecular analyses, optical imaging and electrophysiology to investigat...

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• Ion Channel Gating
• Cell Membrane Permeability
• Cell Size
• Chloride Channels
• Erythrocyte Function and Pathophysiology
• Glyburide
• Guinea Pigs
• Intestines

Identifiers and source

Literature Corpus work

b18e2b4b-0543-553f-bd0c-4047bba72db3

DOI

10.1101/2024.04.03.587990