Article

Membrane cholesterol regulates TRPV4 function, cytoskeletal expression, and the cellular response to tension

2020-12-02

Abstract excerpt

Despite the association of cholesterol with debilitating pressure-related diseases, its role in mechanotransduction is not well understood. We investigated the relationship between mechanical strain, free membrane cholesterol, actin cytoskeleton, and activation of stretch- activated TRPV4 (transient receptor potential vanilloid isoform 4) channel in human trabecular meshwork (TM) cells. Physiological levels of cyc...

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Literature Corpus work: a0e05d3f-1e55-518e-8c33-2650ce0c2cd1
DOI: 10.1101/2020.12.01.406850

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