Article

Targeting YAP mechanosignaling to ameliorate stiffness-induced Schlemm’s canal cell pathobiology

2023-09-10

Abstract excerpt

Pathologic alterations in the biomechanical properties of the Schlemm’s canal (SC) inner wall endothelium and its immediate vicinity are strongly associated with ocular hypertension in glaucoma due to decreased outflow facility. Specifically, the underlying trabecular meshwork is substantially stiffer in glaucomatous eyes compared to that from normal eyes. This raises the possibility of a critical involvement of m...

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Literature Corpus work: 73caf5a2-c124-5af6-954e-f99f1278ad35
DOI: 10.1101/2023.09.08.556840

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