Article

Asymmetric Conservation within Pairs of Co-occurred Motifs Mediates Weak Direct Binding of Transcription Factors in ChIP-seq Data

2020-08-20

Abstract excerpt

<h4>Background: </h4> Transcription factors (TFs) are main regulators of eukaryotic gene expression. The cooperative binding to genomic DNA of at least two TFs is the widespread mechanism of transcription regulation. Cooperating TFs can be revealed through the analysis of co-occurrence of their motifs. <h4>Methods:</h4> We applied Motifs Co-Occurrence Tool (MCOT) that predicted pairs of spaced or overlapped motifs...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 79922d11-7aa8-51a5-a952-57193445ced1
DOI: 10.20944/preprints202007.0639.v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Asymmetric Conservation within Pairs of Co-occurred Motifs Mediates Weak Direct Binding of Transcription Factors in ChIP-seq DataDOI 10.20944/preprints202007.0639.v2Read

A Systematic Study of Motif Pairs That May Facilitate Enhancer-Promoter InteractionsSemantic proximity Read

spatzie: An R package for identifying significant transcription factor motif co-enrichment from enhancer-promoter interactionsSemantic proximity Read

Intrinsic specificity differences between transcription factor paralogs partly explain their differential in vivo bindingSemantic proximity Read

Clustering of Direct and Indirect DNA Binding Motifs of Human and Mouse Transcription Factors: X-TFBS Compendium from ChIP-seqSemantic proximity Read

Discovery of Primary, Cofactor, and Novel Transcription Factor Binding Site Motifs by Recursive, Thresholded Entropy MinimizationSemantic proximity Read

MOCCS profile analysis clarifies the cell type dependency of transcription factor-binding sequences and cis-regulatory SNPs in humansSemantic proximity Read

Conserved DNA-binding motif loci reflect functional transcription factor binding sitesSemantic proximity Read

Analysis of the association between transcription factor binding site variants and distinct accompanying regulatory motifs in yeast.Semantic proximity Read

Uncovering Co-regulatory Modules and Gene Regulatory Networks in the Heart through Machine Learning-based Analysis of Large-scale Epigenomic DataSemantic proximity Read

AmalgaMo: flexible DNA motif mergingSemantic proximity Read

Beyond motif recognition: Specificity of human transcription factors in yeastSemantic proximity Read

Identification of mammalian transcription factors that bind to inaccessible chromatinSemantic proximity Read