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Article

Structural basis of mitochondrial tethering by mitofusin complexes.

Science (New York, N.Y.) - 6 Aug 2004

Koshiba Takumi, Detmer Scott A, Kaiser Jens T, Chen Hsiuchen, McCaffery J Michael, Chan David C

Abstract excerpt

Vesicle fusion involves vesicle tethering, docking, and membrane merger. We show that mitofusin, an integral mitochondrial membrane protein, is required on adjacent mitochondria to mediate fusion, which indicates that mitofusin complexes act in trans (that is, between adjacent mitochondria). A heptad repeat region (HR2) mediates mitofusin oligomerization by assembling a dimeric, antiparallel coiled coil. The...

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Identifiers

PMID: 15297672
DOI: 10.1126/science.1099793

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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