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Mitofusins: Disease Gatekeepers and Hubs in Mitochondrial Quality Control by E3 Ligases

9 May 2019

Abstract excerpt

Mitochondria are dynamic organelles engaged in quality control and aging processes. They constantly undergo fusion, fission, transport, and anchoring events, which empower mitochondria with a very interactive behavior. The membrane remodeling processes needed for fusion require conserved proteins named mitofusins, MFN1 and MFN2 in mammals and Fzo1 in yeast. They are the first determinants deciding on whether...

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PMID: 31156446
DOI: 10.3389/fphys.2019.00517

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