Article

An atlas of protein homo-oligomerization across domains of life

2023-06-11

Abstract excerpt

Protein structures are essential to understand cellular processes in molecular detail. While advances in AI revealed the tertiary structure of proteins at scale, their quaternary structure remains mostly unknown. Here, we describe a scalable strategy based on AlphaFold2 to predict homo-oligomeric assemblies across four proteomes spanning the tree of life. We find that 50% of archaeal, 45% of bacterial, and 20% of...

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Literature Corpus work: a14cbf8f-cfae-5710-926d-3b32369edfab
DOI: 10.1101/2023.06.09.544317

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