Article
OPA1 helical structures give perspective to mitochondrial dysfunction.
Nature - 1 Aug 2023
Nyenhuis Sarah B, Wu Xufeng, Strub Marie-Paule, Yim Yang-In, Stanton Abigail E, Baena Valentina, Syed Zulfeqhar A, Canagarajah Bertram, Hammer John A, Hinshaw Jenny E
Abstract excerpt
Dominant optic atrophy is one of the leading causes of childhood blindness. Around 60-80% of cases1 are caused by mutations of the gene that encodes optic atrophy protein 1 (OPA1), a protein that has a key role in inner mitochondrial membrane fusion and remodelling of cristae and is crucial for the dynamic organization and regulation of mitochondria2. Mutations in OPA1 result in the dysregulation of the...
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