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Article

Physiological functions of mitochondrial fusion.

Annals of the New York Academy of Sciences - 1 Jul 2010

Chen Hsiuchen, Chan David C

Abstract excerpt

In recent years, the dynamic nature of mitochondria has been discovered to be critical for their function. Here we discuss the molecular basis of mitochondrial fusion, its protective role in neurodegeneration, and its importance in cellular function. The mitofusins Mfn1 and Mfn2, GTPases localized to the outer membrane, mediate outer-membrane fusion. OPA1, a GTPase associated with the inner membrane, mediates...

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Source

Identifiers

PMID: 20649534
DOI: 10.1111/j.1749-6632.2010.05615.x

Genes

OPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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