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Article

Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusion.

The Journal of cell biology - 21 Sept 2009

DeVay Rachel M, Dominguez-Ramirez Lenin, Lackner Laura L, Hoppins Suzanne, Stahlberg Henning, Nunnari Jodi

Abstract excerpt

Two dynamin-related protein (DRP) families are essential for fusion of the outer and inner mitochondrial membranes, Fzo1 (yeast)/Mfn1/Mfn2 (mammals) and Mgm1 (yeast)/Opa1 (mammals), respectively. Fzo1/Mfns possess two medial transmembrane domains, which place their critical GTPase and coiled-coil domains in the cytosol. In contrast, Mgm1/Opa1 are present in cells as long (l) isoforms that are anchored via the N...

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Identifiers

PMID: 19752025
DOI: 10.1083/jcb.200906098
PMCID: PMC2753158

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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