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Article

Structural analysis of a trimeric assembly of the mitochondrial dynamin-like GTPase Mgm1.

Proceedings of the National Academy of Sciences of the United States of America - 25 Feb 2020

Yan Liming, Qi Yuanbo, Ricketson Derek, Li Lei, Subramanian Kelly, Zhao Jinghua, Yu Caiting, Wu Lijie, Sarsam Reta, Wong Melissa, Lou Zhiyong, Rao Zihe, Nunnari Jodi, Hu Junjie

Abstract excerpt

The fusion of inner mitochondrial membranes requires dynamin-like GTPases, Mgm1 in yeast and OPA1 in mammals, but how they mediate membrane fusion is poorly understood. Here, we determined the crystal structure of Saccharomyces cerevisiae short Mgm1 (s-Mgm1) in complex with GDP. It revealed an N-terminal GTPase (G) domain followed by two helix bundles (HB1 and HB2) and a unique C-terminal lipid-interacting stalk...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32041880
DOI: 10.1073/pnas.1919116117
PMCID: PMC7049166

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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