Article

Sensor-mediated fine-tuning of siRNA levels is required for spermatogenic piRNA pathway function

2026-03-23

Abstract excerpt

<h4>ABSTRACT</h4> Small RNA pathways provide a robust and dynamic regulatory network that enables spatiotemporal regulation of the germline genome in response to environmental cues. The flexibility of RNA interference (RNAi)-mediated gene regulation and network architecture of these pathways requires molecular mechanisms that can fine-tune their regulatory potential and function to ensure proper execution of phys...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b1627d8c-65c9-51bb-a698-5167e3b4b783
DOI: 10.64898/2026.03.20.713214

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sensor-mediated fine-tuning of siRNA levels is required for spermatogenic piRNA pathway functionDOI 10.64898/2026.03.20.713214Read

RNAi-mediated regulation of <i>alg-3</i> and <i>alg-4</i> coordinates the spermatogenesis developmental program in <i>C. elegans</i>Semantic proximity Read

Tissue- and sex-specific small RNAomes reveal sex differences in response to the environmentSemantic proximity Read

Identification of piRNA binding sites reveals the Argonaute regulatory landscape of the <i>C. elegans</i> germlineSemantic proximity Read

The RNA phosphatase PIR-1 regulates endogenous small RNA pathways in <i>C. elegans</i>Semantic proximity Read

SNPC-1.3 is a sex-specific transcription factor that drives male piRNA expression in <i>C. elegans</i>Semantic proximity Read

Optimal male fertility and fecundity in Caenorhabditis elegans require Microprocessor and Argonaute gene function.Semantic proximity Read

The Upstream Sequence Transcription Complex Dictates Nucleosome Positioning and Promoter Accessibility at piRNA Genes in the <i>C. elegans</i> Germ LineSemantic proximity Read

Golden hamster piRNAs are necessary for early embryonic development and establishment of spermatogoniaSemantic proximity Read

Maternal and zygotic gene regulatory effects of endogenous RNAi pathwaysSemantic proximity Read

A Sex Chromosome piRNA Promotes Robust Dosage Compensation and Sex Determination in C. elegans.Semantic proximity Read

A family of <i>C. elegans</i> VASA homologs control Argonaute pathway specificity and promote transgenerational silencingSemantic proximity Read

piRNAs prevent runaway amplification of siRNAs from ribosomal RNAs and histone mRNAsSemantic proximity Read