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The Upstream Sequence Transcription Complex Dictates Nucleosome Positioning and Promoter Accessibility at piRNA Genes in the <i>C. elegans</i> Germ Line

2023-05-12

Abstract excerpt

<h4>ABSTRACT</h4> The piRNA pathway is a conserved germline-specific small RNA pathway that ensures genomic integrity and continued fertility. In C. elegans and other nematodes, Type-I piRNA precursor transcripts are expressed from over 10,000 small, independently regulated genes clustered within two discrete domains of 1.5 and 3.5 MB on Chromosome IV. These large clusters likely play a significant role in promo...

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Literature Corpus work
d0c4f5cb-2496-50de-bdf9-d2644aea4f6d
DOI
10.1101/2023.05.10.540274
Open publication

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The Upstream Sequence Transcription Complex Dictates Nucleosome Positioning and Promoter Accessibility at piRNA Genes in the <i>C. elegans</i> Germ LineDOI 10.1101/2023.05.10.540274
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