Article

Identification of piRNA binding sites reveals the Argonaute regulatory landscape of the <i>C. elegans</i> germline

2018-02-07

Abstract excerpt

<h4>SUMMARY</h4> piRNAs (Piwi-interacting small RNAs) engage Piwi Argonautes to silence transposons and promote fertility in animal germlines. Genetic and computational studies have suggested that C. elegans piRNAs tolerate mismatched pairing and in principle could target every transcript. Here we employ in vivo cross-linking to identify transcriptome-wide interactions between piRNAs and target RNAs. We show th...

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Literature Corpus work: a82ddb19-cdd0-576a-9ebf-1048c475e760
DOI: 10.1101/262113

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