Article
Alternative splicing of APOBEC3D generates functional diversity and its role as a DNA mutator.
International journal of hematology - 1 Sept 2020
Takei Hisashi, Fukuda Hirofumi, Pan Gilbert, Yamazaki Hiroyuki, Matsumoto Tadahiko, Kazuma Yasuhiro, Fujii Masanori, Nakayama Sohei, Kobayashi Ikei S, Shindo Keisuke, Yamashita Riu, Shirakawa Kotaro, Takaori-Kondo Akifumi, Kobayashi Susumu S
Abstract excerpt
The apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) protein family members have cytidine deaminase activity and can induce cytosine to uracil transition in nucleic acid. The main function of APOBEC3 (A3) proteins is to trigger an innate immune response to viral infections. Recent reports have shown that several APOBEC family proteins such as A3B can induce somatic mutations into genomic...
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