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Article

Systematic discovery of cap-independent translation sequences in human and viral genomes

14 Jan 2016

Abstract excerpt

To investigate gene specificity at the level of translation in both the human genome and viruses, we devised a high-throughput bicistronic assay to quantify cap-independent translation. We uncovered thousands of novel cap-independent translation sequences, and we provide insights on the landscape of translational regulation in both humans and viruses. We find extensive translational elements in the 3'...

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PMID: 26816383
DOI: 10.1126/science.aad4939

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