Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

5′-UTR G-Quadruplex-Mediated Translation Regulation in Eukaryotes: Current Understanding and Methodological Challenges

30 Jan 2025

Abstract excerpt

RNA G-quadruplexes (rG4s) in 5'-UTRs represent complex regulatory elements capable of both inhibiting and activating mRNA translation through diverse mechanisms in eukaryotes. This review analyzes the evolution of our understanding of 5'-UTR rG4-mediated translation regulation, from early discoveries of simple translation inhibitors to the current recognition of their multifaceted regulatory roles. We discuss...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA and protein synthesis mechanisms
Share to RNA Research and Splicing
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39940956
DOI: 10.3390/ijms26031187

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

5′-UTR G-Quadruplex-Mediated Translation Regulation in Eukaryotes: Current Understanding and Methodological ChallengesPMID 39940956Read ↗

RNA G-quadruplexes mark repressive upstream open reading frames in human mRNAsSemantic proximity Read ↗

Reversal of G-Quadruplexes’ Role in Translation Control When Present in the Context of an IRESSemantic proximity Read ↗

RNA G-quadruplexes: emerging mechanisms in disease.Semantic proximity Read ↗

Ribosomal quality control factors inhibit repeat-associated non-AUG translation from GC-rich repeatsSemantic proximity Read ↗

CGG Repeat-Associated Non-AUG Translation Utilizes a Cap-Dependent Scanning Mechanism of Initiation to Produce Toxic Proteins.Semantic proximity Read ↗

Some like it translated: small ORFs in the 5′UTRSemantic proximity Read ↗

The RNA helicase DHX36–G4R1 modulates C9orf72 GGGGCC hexanucleotide repeat–associated translationSemantic proximity Read ↗

FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTDSemantic proximity Read ↗

Unbiased screen of human transcriptome reveals an unexpected role of 3′UTRs in translation initiationSemantic proximity Read ↗

A Helicase Unwinds Hexanucleotide Repeat RNA G-Quadruplexes and Facilitates Repeat-Associated Non-AUG TranslationSemantic proximity Read ↗

FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in <i>C9orf72</i> -linked ALS/FTDSemantic proximity Read ↗

Massively parallel characterization of RNA G-quadruplex stability and molecular recognition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.