Article

RNA G-quadruplexes mark repressive upstream open reading frames in human mRNAs

2017-11-22

Abstract excerpt

<h4>ABSTRACT</h4> RNA secondary structures in the 5’ untranslated regions (UTRs) of mRNAs have been characterised as key determinants of translation initiation. However the role of non-canonical secondary structures, such as RNA G-quadruplexes (rG4s), in modulating translation of human mRNAs and the associated mechanisms remain largely unappreciated. Here we use a ribosome profiling strategy to investigate the tr...

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Literature Corpus work: 3c3b15b8-cb68-5968-8e5b-a51b15246828
DOI: 10.1101/223073

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