Article

5’ UTR recruitment of eIF4GI or DAP5 drives cap-independent translation for a subset of human mRNAs

2018-11-16

Abstract excerpt

During unfavorable human cellular conditions ( e.g ., tumor hypoxia, viral infection, etc .), canonical, cap-dependent mRNA translation is suppressed. Nonetheless, a subset of physiologically important mRNAs ( e.g ., HIF-1α, FGF-9, and p53) is still translated by an unknown, cap-independent mechanism. Additionally, expression levels of eIF4G and its homolog, death associated protein 5 (DAP5), are elevated. Usin...

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Literature Corpus work: c98240e9-a922-56e1-ac51-e4f8662dacfd
DOI: 10.1101/472498

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