Article

FDA-approved PDE4 inhibitors alleviate the dominant toxicity of ALS–FTD-associated CHCHD10S59L by reducing the PINK1/Parkin pathway

2024-09-10

Abstract excerpt

<title>Abstract</title> <bold>Background </bold>Mutations in coiled-coil-helix-coiled-coil-helix domain containing 10 (<italic>CHCHD10</italic>) have been identified as a genetic cause of amyotrophic lateral sclerosis and/or frontotemporal dementia(ALS-FTD). In our previous studies using in vivo <italic>Drosophila</italic> model expressing CHCHD10S59L, and human cell models expressing CHCHD10S5...

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Literature Corpus work: b10b50e2-b606-52a8-9879-5ac1b4c89816
DOI: 10.21203/rs.3.rs-4870330/v1

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