Article

Pharmacological PINK1 activation ameliorates Pathology in Parkinson’s Disease models

2023-02-15

Abstract excerpt

<h4>Summary</h4> PINK1 loss-of-function mutations and exposure to mitochondrial toxins are causative for Parkinson’s disease (PD) and Parkinsonism, respectively. We demonstrate that pathological α-synuclein deposition, the hallmark pathology of idiopathic PD, induces mitochondrial dysfunction and impairs mitophagy, driving accumulation of the PINK1 substrate pS65-Ubiquitin (pUb) in primary neurons and in vivo. We...

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Literature Corpus work: b7c4bb4e-ea0e-55b1-b68e-e725f3fc3944
DOI: 10.1101/2023.02.14.528378

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