Article

FDA-approved PDE4 inhibitors reduce the dominant toxicity of ALS–FTD-associated <i> CHCHD10 <sup>S59L</sup> </i>

2024-06-06

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in coiled-coil-helix-coiled-coil-helix domain containing 10( CHCHD10 ) have been identified as a genetic cause of amyotrophic lateral sclerosis and/or frontotemporal dementia(ALS-FTD). In our previous studies using in vivo Drosophila model expressing C2C10H S81L , and human cell models expressing CHCHD10 S59L , we have identified that the PINK1/Parkin pathway is activated and cause...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a25acf28-c60f-57e8-974b-9f0a8f346a93
DOI: 10.1101/2024.06.04.597429

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

FDA-approved PDE4 inhibitors reduce the dominant toxicity of ALS–FTD-associated <i> CHCHD10 <sup>S59L</sup> </i>DOI 10.1101/2024.06.04.597429Read

FDA-approved PDE4 inhibitors alleviate the dominant toxicity of ALS–FTD-associated CHCHD10S59L by reducing the PINK1/Parkin pathwaySemantic proximity Read

Dominant toxicity of ALS–FTD-associated <i> CHCHD10 <sup>S59L</sup> </i> is mediated by TDP-43 and PINK1Semantic proximity Read

TDP-43 and PINK1 mediate CHCHD10S59L mutation-induced defects in Drosophila and in vitro.Semantic proximity Read

Disruption of Mitophagy Flux through the PARL-PINK1 Pathway by CHCHD10 Mutations or CHCHD10 Depletion.Semantic proximity Read

High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagySemantic proximity Read

SLP2/prohibitins aggregates and instability of the PHB complex are key elements in <i> CHCHD10 <sup>S59L</sup> </i> -related diseaseSemantic proximity Read

CHCHD2 p. Thr61Ile knock‐in mice exhibit motor defects and neuropathological features of Parkinson's diseaseSemantic proximity Read

CHCHD2 and CHCHD10-related neurodegeneration: molecular pathogenesis and the path to precision therapy.Semantic proximity Read

CHCHD10 is involved in the development of Parkinson's disease caused by CHCHD2 loss-of-function mutation p.T61ISemantic proximity Read

Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson's disease caused by CHCHD2.Semantic proximity Read

High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagy.Semantic proximity Read

Differential physical interactions of wild-type and S59L mutant CHCHD10 with mitochondrial proteasesSemantic proximity Read