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Article

CHCHD2 p. Thr61Ile knock‐in mice exhibit motor defects and neuropathological features of Parkinson's disease

2 Nov 2022

Abstract excerpt

The p.Thr61Ile (p.T61I) mutation in coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) was deemed a causative factor in Parkinson's disease (PD). However, the pathomechanism of the CHCHD2 p.T61I mutation in PD remains unclear. Few existing mouse models of CHCHD2-related PD completely reproduce the features of PD, and no transgenic or knock-in (KI) mouse models of CHCHD2 mutations have been reported....

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Identifiers

PMID: 36322611
DOI: 10.1111/bpa.13124

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