Article

Differential physical interactions of wild-type and S59L mutant CHCHD10 with mitochondrial proteases

2024-07-02

Abstract excerpt

Background CHCHD10 is a small mitochondrial protein with a C-terminal coiled-coil-helix–coiled-coil-helix domain. The N-terminal region of CHCHD10 is mostly intrinsically disordered. Therefore, CHCHD10 has no catalytic activity other than protein-protein interactions through the CHCH domain or intrinsically disordered region. The S59L mutation in CHCHD10 has been identified as a genetic cause of amyotrophic latera...

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Literature Corpus work: 917f66ae-7957-568b-be41-21fbb1ed4485
DOI: 10.12688/f1000research.151962.1

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