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Article

High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagy.

SLAS discovery : advancing life sciences R & D - 1 Apr 2023

Tufi Roberta, Clark Emily H, Hoshikawa Tamaki, Tsagkaraki Christiana, Stanley Jack, Takeda Kunitoshi, Staddon James M, Briston Thomas

Abstract excerpt

Mitochondrial dysfunction and aberrant mitochondrial homeostasis are key aspects of Parkinson's disease (PD) pathophysiology. Mutations in PINK1 and Parkin proteins lead to autosomal recessive PD, suggesting that defective mitochondrial clearance via mitophagy is key in PD etiology. Accelerating the identification and/or removal of dysfunctional mitochondria could therefore provide a disease-modifying approach to...

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PMID: 36608804
DOI: 10.1016/j.slasd.2022.12.004

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