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Article

Disruption of Mitophagy Flux through the PARL-PINK1 Pathway by CHCHD10 Mutations or CHCHD10 Depletion.

Cells - 7 Dec 2023

Liu Tian, Wetzel Liam, Zhu Zexi, Kumaraguru Pavan, Gorthi Viraj, Yan Yan, Bukhari Mohammed Zaheen, Ermekbaeva Aizara, Jeon Hanna, Kee Teresa R, Woo Jung-A Alexa, Kang David E

Abstract excerpt

Coiled-coil-helix-coiled-coil-helix domain-containing 10 (CHCHD10) is a nuclear-encoded mitochondrial protein which is primarily mutated in the spectrum of familial and sporadic amyotrophic lateral sclerosis (ALS)-frontotemporal dementia (FTD). Endogenous CHCHD10 levels decline in the brains of ALS-FTD patients, and the CHCHD10S59L mutation in Drosophila induces dominant toxicity together with PTEN-induced kinase...

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Source

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Identifiers

PMID: 38132101
DOI: 10.3390/cells12242781
PMCID: PMC10741529

Genes

CHCHD10
PARL
PINK1
PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Disruption of Mitophagy Flux through the PARL-PINK1 Pathway by CHCHD10 Mutations or CHCHD10 Depletion.PMID 38132101Read ↗

TDP-43 and PINK1 mediate CHCHD10S59L mutation-induced defects in Drosophila and in vitro.Semantic proximity Read ↗

Dominant toxicity of ALS–FTD-associated <i> CHCHD10 <sup>S59L</sup> </i> is mediated by TDP-43 and PINK1Semantic proximity Read ↗

Differential physical interactions of wild-type and S59L mutant CHCHD10 with mitochondrial proteasesSemantic proximity Read ↗

CHCHD10-regulated OPA1-mitofilin complex mediates TDP-43-induced mitochondrial phenotypes associated with frontotemporal dementia.Semantic proximity Read ↗

Modulation of synaptic plasticity, motor unit physiology, and TDP-43 pathology by CHCHD10Semantic proximity Read ↗

SLP2/prohibitins aggregates and instability of the PHB complex are key elements in <i> CHCHD10 <sup>S59L</sup> </i> -related diseaseSemantic proximity Read ↗

FDA-approved PDE4 inhibitors reduce the dominant toxicity of ALS–FTD-associated <i> CHCHD10 <sup>S59L</sup> </i>Semantic proximity Read ↗

FDA-approved PDE4 inhibitors alleviate the dominant toxicity of ALS–FTD-associated CHCHD10S59L by reducing the PINK1/Parkin pathwaySemantic proximity Read ↗

Pathological characterization of a novel mouse model expressing the PD-linked CHCHD2-T61I mutation.Semantic proximity Read ↗

CHCHD2 and CHCHD10-related neurodegeneration: molecular pathogenesis and the path to precision therapy.Semantic proximity Read ↗

CHCHD10 and SLP2 control the stability of the PHB complex: a key factor for motor neuron viabilitySemantic proximity Read ↗

In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions.Semantic proximity Read ↗

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