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Article

Genetic and Chemical Activation of TFEB Mediates Clearance of Aggregated α-Synuclein

19 Mar 2015

Abstract excerpt

Aggregation of α-synuclein (α-syn) is associated with the development of a number of neurodegenerative diseases, including Parkinson's disease (PD). The formation of α-syn aggregates results from aberrant accumulation of misfolded α-syn and insufficient or impaired activity of the two main intracellular protein degradation systems, namely the ubiquitin-proteasome system and the autophagy-lysosomal pathway. In...

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PMID: 25790376
DOI: 10.1371/journal.pone.0120819

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