Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The regulatory mechanism and therapeutic potential of transcription factor <scp>EB</scp> in neurodegenerative diseases

2 Oct 2022

Abstract excerpt

The autophagy-lysosomal pathway (ALP) is involved in the degradation of protein aggregates and damaged organelles. Transcription factor EB (TFEB), a major regulator of ALP, has emerged as a leading factor in addressing neurodegenerative disease pathology, including Alzheimer's disease (AD), Parkinson's disease (PD), PolyQ diseases, and Amyotrophic lateral sclerosis (ALS). In this review, we delineate the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Nuclear Receptors and Signaling
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36184826
DOI: 10.1111/cns.13985

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The regulatory mechanism and therapeutic potential of transcription factor <scp>EB</scp> in neurodegenerative diseasesPMID 36184826Read ↗

Novel Insight into Functions of Transcription Factor EB (TFEB) in Alzheimer’s Disease and Parkinson’s DiseaseSemantic proximity Read ↗

Therapeutic Potential of Vital Transcription Factors in Alzheimer’s and Parkinson’s Disease With Particular Emphasis on Transcription Factor EB Mediated AutophagySemantic proximity Read ↗

TFEB in Alzheimer's disease: From molecular mechanisms to therapeutic implicationsSemantic proximity Read ↗

From the regulatory mechanism of TFEB to its therapeutic implicationsSemantic proximity Read ↗

TFEB Biology and Agonists at a GlanceSemantic proximity Read ↗

Transcription factor EB: from master coordinator of lysosomal pathways to candidate therapeutic target in degenerative storage diseasesSemantic proximity Read ↗

The Role and Regulatory Mechanism of Transcription Factor EB in Health and DiseasesSemantic proximity Read ↗

Transcription factor EB: an emerging drug target for neurodegenerative disordersSemantic proximity Read ↗

Genetic and Chemical Activation of TFEB Mediates Clearance of Aggregated α-SynucleinSemantic proximity Read ↗

TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunitiesSemantic proximity Read ↗

TFEB acetylation promotes lysosome biogenesis and ameliorates Alzheimer's disease-relevant phenotypes in mice.Semantic proximity Read ↗

TFEB and TFE3 have cell-type specific expression in the brain and divergent roles in neuronsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.