Genetic association of apolipoprotein E with age-related macular degeneration.

doi:10.1086/301901

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Article

Genetic association of apolipoprotein E with age-related macular degeneration.

American journal of human genetics - 1 Jul 1998

Klaver C C, Kliffen M, van Duijn C M, Hofman A, Cruts M, Grobbee D E, van Broeckhoven C, de Jong P T

Abstract excerpt

Age-related macular degeneration (AMD) is the most common geriatric eye disorder leading to blindness and is characterized by degeneration of the neuroepithelium in the macular area of the eye. Apolipoprotein E (apoE), the major apolipoprotein of the CNS and an important regulator of cholesterol and lipid transport, appears to be associated with neurodegeneration. The apoE gene (APOE) polymorphism is a strong...

Topics

Aged
Alleles
Apolipoproteins E
Genotype
Humans
Immunochemistry
Macula Lutea
Macular Degeneration
Middle Aged
Netherlands
Polymorphism, Genetic
Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 9634502
DOI: 10.1086/301901
PMCID: PMC1377225

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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