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Article

Genetic association of apolipoprotein E with age-related macular degeneration.

American journal of human genetics - 1 Jul 1998

Klaver C C, Kliffen M, van Duijn C M, Hofman A, Cruts M, Grobbee D E, van Broeckhoven C, de Jong P T

Abstract excerpt

Age-related macular degeneration (AMD) is the most common geriatric eye disorder leading to blindness and is characterized by degeneration of the neuroepithelium in the macular area of the eye. Apolipoprotein E (apoE), the major apolipoprotein of the CNS and an important regulator of cholesterol and lipid transport, appears to be associated with neurodegeneration. The apoE gene (APOE) polymorphism is a strong...

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Source

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Identifiers

PMID: 9634502
DOI: 10.1086/301901
PMCID: PMC1377225

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Genetic association of apolipoprotein E with age-related macular degeneration.PMID 9634502Read ↗

Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies.Semantic proximity Read ↗

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Apolipoprotein E Isoforms and AMD.Semantic proximity Read ↗

Apolipoprotein E polymorphisms in age-related macular degeneration in an Italian population.Semantic proximity Read ↗

Association of apolipoprotein E alleles with susceptibility to age-related macular degeneration in a large cohort from a single center.Semantic proximity Read ↗

Associations of Alzheimer Disease-Protective APOE Variants With Age-Related Macular Degeneration.Semantic proximity Read ↗

The role of apolipoprotein E (rs7412 and rs429358) in age-related macular degeneration.Semantic proximity Read ↗

Association of the apolipoprotein E gene with age-related macular degeneration: possible effect modification by family history, age, and gender.Semantic proximity Read ↗

Age-related macular degeneration and functional promoter and coding variants of the apolipoprotein E gene.Semantic proximity Read ↗

The epsilon2 and epsilon4 alleles of the apolipoprotein gene are associated with age-related macular degeneration.Semantic proximity Read ↗

Apolipoprotein E genotype and risk for development of cataract and age-related macular degeneration.Semantic proximity Read ↗

APOE Impacts Lipid Trafficking in Retinal Pigment Epithelium CellsSemantic proximity Read ↗

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