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Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration

25 Mar 2025

Abstract excerpt

Hallmark findings in age-related macular degeneration (AMD) include the accumulation of extracellular lipid and vasodegeneration of the choriocapillaris. Choroidal inflammation has long been associated with AMD, but little is known about the immune landscape of the human choroid. Using 3D multiplex immunofluorescence, single-cell RNA sequencing, and flow cytometry, we unravel the cellular composition and spatial...

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PMID: 40261298
DOI: 10.1084/jem.20242007

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