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Article

Retinal pigment epithelium-specific CLIC4 mutant is a mouse model of dry age-related macular degeneration.

Nature communications - 18 Jan 2022

Chuang Jen-Zen, Yang Nan, Nakajima Nobuyuki, Otsu Wataru, Fu Cheng, Yang Howard Hua, Lee Maxwell Ping, Akbar Armaan Fazal, Badea Tudor Constantin, Guo Ziqi, Nuruzzaman Afnan, Hsu Kuo-Shun, Dunaief Joshua L, Sung Ching-Hwa

Abstract excerpt

Age-related macular degeneration (AMD) is the leading cause of blindness among the elderly. Dry AMD has unclear etiology and no treatment. Lipid-rich drusen are the hallmark of dry AMD. An AMD mouse model and insights into drusenogenesis are keys to better understanding of this disease. Chloride intracellular channel 4 (CLIC4) is a pleomorphic protein regulating diverse biological functions. Here we show that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35042858
DOI: 10.1038/s41467-021-27935-9
PMCID: PMC8766482

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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