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Article

Regulated expression of apolipoprotein E by human retinal pigment epithelial cells.

Journal of lipid research - 1 Feb 2004

Ishida Brian Y, Bailey Kathy R, Duncan Keith G, Chalkley Robert J, Burlingame A L, Kane John P, Schwartz Daniel M

Abstract excerpt

In early age-related macular degeneration (AMD), lipid-containing deposits (drusen) accumulate in Bruch's membrane underlying the retinal pigment epithelium (RPE). Recent studies indicate that apolipoprotein E (apoE) may play a role in lipid trafficking in AMD. Compared with the apoE3 allele, the apoE4 and apoE2 alleles are associated with decreased and increased risk for AMD, respectively; drusen contain high...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14594998
DOI: 10.1194/jlr.M300306-JLR200

Genes

RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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