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Article

Aged human iPSC-RPE organoid cultures display hallmarks of drusen formation

2021-10-12

Abstract excerpt

Age-related macular degeneration (AMD) is among the most common causes of irreversible vision loss. Disease progression is strongly associated with age-related pathological changes of retinal pigment epithelial (RPE) cells, such as accumulation of intracellular lipid-containing cell debris, extracellular lipid-rich deposits (drusen) and collagen-rich basal laminar deposits. Current AMD models provide a limited und...

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Identifiers and source

Literature Corpus work
39136371-5abb-5d12-aefe-fc9744ba5782
DOI
10.1101/2021.10.12.463899
Open publication

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