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Cellular and population level processes influence the rate, accumulation and observed frequency of inherited and somatic mtDNA mutations.

Mutagenesis - 1 May 2017

Melvin Richard G, Ballard John William O

Abstract excerpt

Mitochondria are found in all animals and have the unique feature of containing multiple copies of their own small, circular DNA genome (mtDNA). The rate and pattern of mutation accumulation in the mtDNA are influenced by molecular, cellular and population level processes. We distinguish between inherited and somatic mtDNA mutations and review evidence for the often-made assumption that mutations accumulate at a...

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Identifiers

PMID: 28521046
DOI: 10.1093/mutage/gex004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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