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Article

Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer.

Molecular biology of the cell - 1 Jun 2012

Jia Da, Gomez Timothy S, Billadeau Daniel D, Rosen Michael K

Abstract excerpt

Wiskott-Aldrich syndrome protein (WASPs) control actin dynamics in cellular processes, including cell motility, receptor-mediated endocytosis, bacterial invasion, and vesicular trafficking. We demonstrated that WASH, a recently identified WASP family protein, colocalizes on endosomal subdomains with the cargo-selective complex (CSC) of the retromer, where it regulates retrograde sorting from endosomes in an...

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Source

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Identifiers

PMID: 22513087
DOI: 10.1091/mbc.E11-12-1059
PMCID: PMC3374753

Genes

VPS35

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer.PMID 22513087Read ↗

Retromer-mediated recruitment of the WASH complex involves discrete interactions between VPS35, VPS29, and FAM21.Semantic proximity Read ↗

Retromer-mediated recruitment of the WASH complex involves discrete interactions between VPS35, VPS29 and Fam21Semantic proximity Read ↗

Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complexSemantic proximity Read ↗

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes.Semantic proximity Read ↗

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Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagySemantic proximity Read ↗

ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes.Semantic proximity Read ↗

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