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Article

Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy

13 May 2014

Abstract excerpt

Endosomal protein sorting controls the localization of many physiologically important proteins and is linked to several neurodegenerative diseases. VPS35 is a component of the retromer complex, which mediates endosome-to-Golgi retrieval of membrane proteins such as the cation-independent mannose 6-phosphate receptor. Furthermore, retromer is also required for the endosomal recruitment of the actin nucleation...

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PMID: 24819384
DOI: 10.1038/ncomms4828

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Related research

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Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagyPMID 24819384Read ↗

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