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Article

Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage.

Current biology : CB - 25 Jul 2006

Colombani Julien, Polesello Cédric, Josué Filipe, Tapon Nicolas

Abstract excerpt

Developmental and environmental signals control a precise program of growth, proliferation, and cell death. This program ensures that animals reach, but do not exceed, their typical size . Understanding how cells sense the limits of tissue size and respond accordingly by exiting the cell cycle or undergoing apoptosis has important implications for both developmental and cancer biology. The Hippo (Hpo) pathway...

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Identifiers

PMID: 16860746
DOI: 10.1016/j.cub.2006.05.059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage.PMID 16860746Read ↗

The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis.Semantic proximity Read ↗

hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts.Semantic proximity Read ↗

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.Semantic proximity Read ↗

The Drosophila RASSF homolog antagonizes the hippo pathway.Semantic proximity Read ↗

Elucidation of a universal size-control mechanism in Drosophila and mammals.Semantic proximity Read ↗

The role of the Hippo pathway in human disease and tumorigenesisSemantic proximity Read ↗

The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control.Semantic proximity Read ↗

A screen for conditional growth suppressor genes identifies the Drosophila homolog of HD-PTP as a regulator of the oncoprotein Yorkie.Semantic proximity Read ↗

The bantam microRNA is a target of the hippo tumor-suppressor pathway.Semantic proximity Read ↗

Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling.Semantic proximity Read ↗

The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila.Semantic proximity Read ↗

The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway.Semantic proximity Read ↗

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