Article
Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway.
Current biology : CB - 7 Nov 2006
Bennett F Christian, Harvey Kieran F
Abstract excerpt
BACKGROUND: The atypical Fat cadherin has long been known to control cell proliferation and organ size in Drosophila, but the mechanism by which Fat controls these processes has remained elusive. A newly emerging signaling pathway that controls organ size during development is the Salvador/Warts/Hippo pathway. RESULTS: Here we demonstrate that Fat limits organ size by modulating activity of the...
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