Article
The Hippo signalling pathway coordinates organ growth and limits developmental variability by controlling dilp8 expression.
Nature communications - 22 Nov 2016
Boone Emilie, Colombani Julien, Andersen Ditte S, Léopold Pierre
Abstract excerpt
Coordination of organ growth during development is required to generate fit individuals with fixed proportions. We recently identified Drosophila Dilp8 as a key hormone in coupling organ growth with animal maturation. In addition, dilp8 mutant flies exhibit elevated fluctuating asymmetry (FA) demonstrating a function for Dilp8 in ensuring developmental stability. The signals regulating Dilp8 activity during...
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