Article
Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila.
Development (Cambridge, England) - 1 Dec 2002
Kango-Singh Madhuri, Nolo Riitta, Tao Chunyao, Verstreken Patrik, Hiesinger P Robin, Bellen Hugo J, Halder Georg
Abstract excerpt
During animal development, organ size is determined primarily by the amount of cell proliferation, which must be tightly regulated to ensure the generation of properly proportioned organs. However, little is known about the molecular pathways that direct cells to stop proliferating when an organ has attained its proper size. We have identified mutations in a novel gene, shar-pei, that is required for proper...
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