Article
Elucidation of a universal size-control mechanism in Drosophila and mammals.
Cell - 21 Sept 2007
Dong Jixin, Feldmann Georg, Huang Jianbin, Wu Shian, Zhang Nailing, Comerford Sarah A, Gayyed Mariana F, Anders Robert A, Maitra Anirban, Pan Duojia
Abstract excerpt
Coordination of cell proliferation and cell death is essential to attain proper organ size during development and for maintaining tissue homeostasis throughout postnatal life. In Drosophila, these two processes are orchestrated by the Hippo kinase cascade, a growth-suppressive pathway that ultimately antagonizes the transcriptional coactivator Yorkie (Yki). Here we demonstrate that a single phosphorylation site...
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