Article

Loss of catalytic activity and impaired proteostasis in guanosine nucleotide-depleted LRRK2

2026-04-23

Abstract excerpt

<h4>Summary</h4> Coding mutations in the Leucine-rich repeat kinase 2 ( LRRK2 ) gene represent the most common cause of familial Parkinson’s disease (PD), and are frequently observed in idiopathic PD. In addition, variation around the LRRK2 locus has been shown to alter PD risk by genome-wide association studies. Disease-causing mutations cluster within the catalytic core of LRRK2 – composed of GTPase (ROC) an...

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Literature Corpus work: b08ea27f-d435-5b28-a567-6299fbaba700
DOI: 10.64898/2026.04.21.719846

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