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Single cell multi-omic analysis identifies a <i>Tbx1</i> -dependent multilineage primed population in the murine cardiopharyngeal mesoderm

2020-12-24

Abstract excerpt

The poles of the heart and branchiomeric muscles of the face and neck are formed from the cardiopharyngeal mesoderm (CPM) within the pharyngeal apparatus. The formation of the cardiac outflow tract and branchiomeric muscles are disrupted in patients with 22q11.2 deletion syndrome (22q11.2DS), due to haploinsufficiency of TBX1 , encoding a T-box transcription factor. Here, using single cell RNA-sequencing, we iden...

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Identifiers and source

Literature Corpus work
7ac3577f-487b-587a-8434-f14333831c98
DOI
10.1101/2020.12.24.424342
Open publication

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Single cell multi-omic analysis identifies a <i>Tbx1</i> -dependent multilineage primed population in the murine cardiopharyngeal mesodermDOI 10.1101/2020.12.24.424342
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