Article

Single cell transcriptomics reveal temporal dynamics of critical regulators of germ cell fate during mouse sex determination

2019-08-29

Abstract excerpt

<h4>Summary</h4> Despite the importance of germ cell (GC) differentiation for sexual reproduction, the gene networks underlying their fate remain unclear. Here, we comprehensively characterize the gene expression dynamics during sex determination based on single-cell RNA sequencing of 14,914 XX and XY mouse GCs between embryonic days (E) 9.0 and 16.5. We found that XX and XY GCs diverge transcriptionally as early...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8a49149f-5273-51fe-952b-f16922f03d84
DOI: 10.1101/747279

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single cell transcriptomics reveal temporal dynamics of critical regulators of germ cell fate during mouse sex determinationDOI 10.1101/747279Read

Single-cell transcriptomics of the mouse gonadal soma reveals the establishment of sexual dimorphism in distinct cell lineagesSemantic proximity Read

Deciphering Cell Lineage Specification during Male Sex Determination with Single-Cell RNA SequencingSemantic proximity Read

Deciphering cell lineage specification during male sex determination with single-cell RNA sequencingSemantic proximity Read

Single cell RNA sequencing reveals the landscape of early female germ cell developmentSemantic proximity Read

Genetic and genomic insights into male reproductive tract development.Semantic proximity Read

Dissecting the initiation of female meiosis in the mouse at single-cell resolutionSemantic proximity Read

Cell-fate transition and determination analysis of mouse male germ cells throughout developmentSemantic proximity Read

Comparative developmental genomics of sex-biased gene expression in early embryogenesis across mammalsSemantic proximity Read

Dissecting Human Gonadal Cell Lineage Specification and Sex Determination Using a Single-Cell RNA-Seq ApproachSemantic proximity Read

The construction of a testis transcriptional cell atlas from embryo to adult reveals various somatic cells and their molecular rolesSemantic proximity Read

New Candidate Genes Identified for Controlling Mouse Gonadal Sex Determination and the Early Stages of Granulosa and Sertoli Cell Differentiation1Semantic proximity Read

Spatial Transcriptomics Reveals the Temporal Architecture of the Seminiferous Epithelial Cycle and Precise Sertoli-Germ SynchronizationSemantic proximity Read