Article

uORFlight: a vehicle towards uORF-mediated translational regulation mechanisms in eukaryotes

2019-07-24

Abstract excerpt

Upstream open reading frames (uORFs) are prevalent in eukaryotic mRNAs. They act as a translational control element for precisely tuning the expression of the downstream major open reading frame (mORF) with essential cellular functionalities. uORF variation has been clearly associated with several human diseases. In contrast, natural uORF variants in plants have not ever been identified or linked with any phenotyp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b07d5829-9fa7-5f38-9186-eb34ca3b3230
DOI: 10.1101/713321

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

uORFlight: a vehicle towards uORF-mediated translational regulation mechanisms in eukaryotesDOI 10.1101/713321Read

uORFlight: a vehicle toward uORF-mediated translational regulation mechanisms in eukaryotes.Semantic proximity Read

uORFdb--a comprehensive literature database on eukaryotic uORF biology.Semantic proximity Read

Gene expression regulation by upstream open reading frames and human disease.Semantic proximity Read

<i>uORF-Tools</i> – Workflow for the determination of translation-regulatory upstream open reading framesSemantic proximity Read

Upstream Open Reading Frames (uORFs) in the Apicomplexan Parasites <em>Plasmodium falciparum</em> and <em>Toxoplasma gondii</em>: Small yet Powerful Regulators of TranslationSemantic proximity Read

Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.Semantic proximity Read

Analysis of human upstream open reading frames and impact on gene expression.Semantic proximity Read

Some like it translated: small ORFs in the 5′UTRSemantic proximity Read

Upstream open reading frames: molecular switches in (patho)physiology.Semantic proximity Read

Translation of numerous upstream open reading frames rather than their products is essential for proliferation of human cells of distinct originSemantic proximity Read

An expanded reference catalog of translated open reading frames for biomedical researchSemantic proximity Read

A comprehensive catalog of predicted functional upstream open reading frames in humans.Semantic proximity Read