Back to search

Article

Antagonism of the azoles to olorofim and cross-resistance are governed by linked transcriptional networks in <i>Aspergillus fumigatus</i>

2021-11-18

Abstract excerpt

Aspergillosis, in its various manifestations, is a major cause of morbidity and mortality. Very few classes of antifungal drugs have been approved for clinical use to treat these diseases and resistance to the first line therapeutic class, the triazoles, is increasing. A new class of antifungals that target pyrimidine biosynthesis, the orotomides, are currently in development with the first compound in this class,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b07443b0-16c7-542d-8780-38ec589753f8
DOI
10.1101/2021.11.18.469075
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Antagonism of the azoles to olorofim and cross-resistance are governed by linked transcriptional networks in <i>Aspergillus fumigatus</i>DOI 10.1101/2021.11.18.469075
Olorofim and the azoles are antagonistic in A. fumigatus and functional genomic screens reveal mechanisms of cross resistance.Semantic proximity
Antagonism of the Azoles to Olorofim and Cross-Resistance Are Governed by Linked Transcriptional Networks in Aspergillus fumigatusSemantic proximity
Targeting epigenetic regulators to overcome drug resistance in the emerging human fungal pathogen Candida aurisSemantic proximity
The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatusSemantic proximity
Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulationSemantic proximity
Resistance profiling of <i>Aspergillus fumigatus</i> to olorofim indicates absence of intrinsic resistance and unveils the molecular mechanisms of acquired olorofim resistanceSemantic proximity
Loss of a conserved C-terminal region of the <i>Aspergillus fumigatus</i> AtrR transcriptional regulator leads to a gene-specific defect in target gene expressionSemantic proximity
A screen to identify antifungal antagonists reveals a variety of pharmacotherapies induce echinocandin tolerance in <i>Candida albicans</i>Semantic proximity
A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1.Semantic proximity
A long non-coding RNA regulates in vitro and in vivo triazole antifungal susceptibility in <i>Aspergillus fumigatus</i>Semantic proximity
tRNA hypomodification facilitates 5-fluorocytosine resistance via cross-pathway control system activation in <i>Aspergillus fumigatus</i>Semantic proximity
Polygenetic Determinants of Azole Resistance, Tolerance, and Heteroresistance in <i>Candida albicans</i>Semantic proximity
Select a neighboring publication to make it the new centre.