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Resistance profiling of <i>Aspergillus fumigatus</i> to olorofim indicates absence of intrinsic resistance and unveils the molecular mechanisms of acquired olorofim resistance

2021-11-17

Abstract excerpt

Olorofim (F901318) is a new antifungal currently under clinical development that shows both in vitro and in vivo activity against a number of filamentous fungi including Aspergillus fumigatus . In this study we screened A. fumigatus isolates for intrinsic olorofim-resistant A. fumigatus and evaluated the ability of A. fumigatus to acquire an olorofim-resistant phenotype. No intrinsic resistance was found in 97...

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Literature Corpus work
32f616af-8be2-59d6-a301-6292bf6b290e
DOI
10.1101/2021.11.16.468917
Open publication

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Resistance profiling of <i>Aspergillus fumigatus</i> to olorofim indicates absence of intrinsic resistance and unveils the molecular mechanisms of acquired olorofim resistanceDOI 10.1101/2021.11.16.468917
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