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Olorofim and the azoles are antagonistic in A. fumigatus and functional genomic screens reveal mechanisms of cross resistance.

2021-11-18

Abstract excerpt

<title>Abstract</title> <p>Aspergillosis, in its various manifestations, is a major cause of morbidity and mortality. Very few classes of antifungal have been approved for clinical use to treat these diseases and resistance to the first line therapeutics is increasing. A new class of antifungals, the orotomides, are currently in development with the first compound in this class olorofim in late-stage clinical tri...

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Literature Corpus work
fa446833-12e5-550c-9cb3-ba15532cd801
DOI
10.21203/rs.3.rs-1079988/v1
Open publication

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Olorofim and the azoles are antagonistic in A. fumigatus and functional genomic screens reveal mechanisms of cross resistance.DOI 10.21203/rs.3.rs-1079988/v1
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