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tRNA hypomodification facilitates 5-fluorocytosine resistance via cross-pathway control system activation in <i>Aspergillus fumigatus</i>

2024-02-19

Abstract excerpt

<h4>ABSTRACT</h4> Increasing antifungal drug resistance is a major concern associated with human fungal pathogens like Aspergillus fumigatus . Genetic mutation and epimutation mechanisms clearly drive resistance, yet the epitranscriptome remains relatively untested. Here, deletion of the A. fumigatus tRNA-modifying isopentenyl transferase ortholog, Mod5, led to altered stress response and unexpected resistance...

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Literature Corpus work
6b8255f0-9205-596b-ac02-c08a1a59de19
DOI
10.1101/2024.02.19.578369
Open publication

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tRNA hypomodification facilitates 5-fluorocytosine resistance via cross-pathway control system activation in <i>Aspergillus fumigatus</i>DOI 10.1101/2024.02.19.578369
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